Resource Hub

The SRG RAT® Displays More Human Tumor Characteristics and Interactions versus the NSG Mouse: Implications for Safety and Efficacy Testing

The MCF-7 Breast Cancer Model: A Definitive Guide

The Hera Biolabs Guide to the MCF-7 Breast Cancer Model - history, ongoing applications, and its future relevance to oncology studies.

Advantages of Utilizing the SRG rat for Investigating Tumor Metastasis

A Fred Hutch research team employed SRG rats as a model organism to improve the detection of dissemination events. Through this approach, they identified a significant increase in the abundance of circulating tumor cells (CTCs).

The SRG OncoRat for Precision Cancer Medicine

Cell Line Development

Frequently Asked Questions about the SRG™ Rat

SRG OncoRat , a SCID Model Ideal for Human Xenografts

Pre-clinical testing of oncology drugs can be costly and less effective. Read our datasheet and discover how oncology drug developers can benefit from our Hera SRG OncoRat.

Ovarian Cancer Studies in the SRG OncoRat

Read our datasheet and learn how our Hera SRG OncoRat® is preferred for ovarian cancer PDX studies. Reach out to us on how to incorporate in your research.

Prostate Cancer Studies in the SRG OncoRat

Learn about our SRG rat for oncology, how our this OncoRat aids prostate cancer studies, as well as services at Hera with PDX and standard of care options. Contact us to learn more.

Frequently Asked Questions about the SRG^™ Rat

Evolution Of The Rat Model

Rat models for preclinical oncology research have evolved and their functionality for xenograft studies greatly surpasses matched mouse models.

SRG™ Rat (OncoRat^®) Enables Precision Medicine-Based Cancer Studies

Review of data showing high efficiency tumor take rates, growth kinetics, and successful precision medicine with difficult cell lines and PDXs

Syngeneic Orthotopic Brain Cancer Xenografts In Rats

Learn how our highly immunocompromised rat model, the SRG Rat™ provides an advantage in orthotopic brain cancer research for better clinical interventions.

Rapid Creation of Bioluminescent Cell Lines for Orthotopic and Metastatic Rodent Oncology Studies

In vivo bioluminescent imaging in the SRGTM OncoRat® provides an ideal platform for de-risking your pipeline and developing life-saving pharmacotherapies.

The SRG OncoRat for Precision Cancer Medicine

In Vivo Gene Delivery Using piggyBac With Hydrodynamic Tail Vein Injection

Overview and data describing how mutant human KRAS cell lines are highly compatible with our SRG OncoRat animal research model

In Vivo Gene Delivery Using piggyBac With Hydrodynamic Tail Vein Injection

New Connection Between Gut Microbes And Liver Cancer Uncovered In Mice

Researchers uncovered a unique mechanism in which gut microbes have the ability to influence the immune response against nearby liver tumors observed in mice.

Emerging Trends: Utilizing Humanized Rat Models For Investigating Strategies Against HIV And Associated Pathologies

Utilize the latest advancement in humanized rat models against HIV, just like Hera BioLab's OncoRat platform. Contact us today to learn more information.

2019 AACR: OncoRat SRG: enabling xenografts and humanizing the immune system

2018 American Association for Cancer Research (AACR) Annual Meeting poster. The SRG™ rat: A novel SCID rat for humanization studies

2019 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. A Rag2/Il2rg double-knockout rat supports engraftment of human immune system for immunotherapy-based cancer efficacy studies

Hera’s talk at Scientist.com on using the SRG rat for the 3Rs

A Fully Immunodeficient Rat Model

HeraBioLabs | Ramesh Narayanan

HeraBioLabs | Goutham Narla

HeraBioLabs | Fallon Noto

The OncoRat® Is The Ideal Host For Patient-Derived Xenografts Of Ovarian Cancer Cells

Advances in cytotoxic, platinum-based chemotherapeutics combined with tumor resection surgery allows approximately 80% of these patients to achieve remission.

Hera Biolabs Announces Molecular Cancer Therapeutics Publication On Immunodeficient Rats For Oncology Research

Hera Biolabs, the University of Michigan, Case Western Reverse University and other collaborators are announcing a recent publication in the American Association for Cancer Research (AACR) journal, Molecular Cancer Therapeutics, entitled, "Sprague Dawley Rag2-null rats created from engineered spermatogonial stem cells are immunodeficient and permissive to human xenografts."

Breakthroughs In Gene Editing Allow For The Creation Of Superior Preclinical Oncology Models

Hera Biolabs has used its proprietary gene editing technologies to develop ideal rat models for use in pre-clinical oncology research by oncology CROs.

Understanding Transporter-Mediated Drug-Drug Interactions Using Humanized Liver Mice

Humanized liver mice such as PXB and TK-NOG mice could play an important role in drug discovery and the evaluation of DDIs in a preclinical setting.

Humanized Mouse Models Advance Immunotherapeutic Strategies In Treatment Of Type 1 Diabetes

The future holds with regards to the treatment of T1D and this could be a major breakthrough in the understanding of the disease.

Humanized Mice Allow For Better Understanding Of Interactions Between VACV & Immune System

“Creating a favorable microenvironment for induction of optimal anti-tumor immune responses” are urgently needed to move the needle forward on VACV-based treatments in a clinical environment.

Humanized Mouse Model Allows For Study Of Immune Response To Decellularized ECM Biomaterials

Humanized mouse models will allow for further study of human immune cell responses to biomaterials in an in vivo environment.

Early Discovery In Rats And Humanized Rodents

We offer a range of preliminary in vivo capabilities as well as the ability to screen compounds in both traditional animal rodent models.

HIS Mice Provide New Preclinical Model For Human Skin Immunity

By injecting this model with human antigen-presenting cells (APC) at the treatment site, Centlivre et al were able to invoke an immune response in the HIS mouse.

What’s Old Is New Again: Chemical Carcinogenesis Models Of Cancer

In vivo chemical carcinogenesis models may just have what it takes for researchers to better understand the necessary pathways to prevent, treat and ultimately cure human cancer.

New Mouse Model Enables In Vivo Assessment Of Immunotherapies For Treating CGD

New humanized NSG mouse xenograft prove research surrounding other human phagocyte deficiencies and in the study of infections frequently associated with human cell transplant procedures.

Chimeric Humanized Mouse Models: Understanding Human And Mouse Cell Interactions

A result of the species mismatch between human and mouse cells certain deficiencies are increasingly common.

piggyBac Creates Human SIRPA BAC Transgenic Rat Models

Overview of obtaining human SIRPA BAC transgenic rat models for preclinical research using piggyBac transposase/transposon gene editing.

Humanized Mouse Models Give Hope To Allergy Research

The newly created BLT humanized mouse model offers tremendous implications for the future of allergy research and gives hope that a rat model with a humanized immune system.

The SRG Rat for combined drug efficacy, pharmacokinetics, and toxicology studies

The SRG Rat for intracranial patient-derived xenografts

The highly immunodeficient SRG Rat for modeling diabetes

Comparative pathology of the immunodeficient SRG Rat for human xenograft and toxicology studies

Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer ANGPTL7

In vivo subcutaneous and orthotopic cancer xenograft modeling in the SRG Rat

Comparative CBC, serum chemistry, and immune phenotype between SRG and CD rats

A murine model for chronic liver-specific oligonucleotide efficacy testing

Targeting ribonucleotide reductase induces synthetic lethality in PP2A-deficient uterine serous carcinoma

In vivo imaging of ovarian and non-small cell lung cancer models hosted in the SRG Rat

The SRG Rat has enhanced tumor microenvironment in human prostate cancer xenografts

Androgen receptor gegrader for enzalutamide-resistant prostate cancer

Local injection of submicron particle docetaxel is associated with tumor eradication in uro-oncologic xenografts

Hera’s talk at Scientist.com on using the SRG rat for the 3Rs

The SRG Rat rat supports engraftment of human immune system for immunotherapy-based studies

Rag2-null rats are immunodeficient and permissive to human xenografts

View Our Webinar On The OncoRat For Xenografts And PDX

Novel immunodeficient rat models offers a unique platform for drug efficacy studies in human tumor xenografts

A Novel Immunodeficient Rat for Modeling Human Cancer

Novel immunodeficient rat models capable of supporting the growth of human tumor xenografts