The SRG has a SCID rat phenotype and accepts human tissue as a xenograft model. OncoRat has been validated with a wide range of xenograft models including patient derived xenografts (PDX) and consistently demonstrates improved tumor take-rates and delivers tumor sizes 10x that of mouse models in half the time. For translational research, the rat produces blood and tissue samples ten times larger than mice and is metabolically closer to humans. Since the rat is the preferred model for pharmacokinetics (PK) and toxicology, OncoRat is ideally suited for efficacy and PK/toxicology studies in the same animal.
The SRG Platform can also be reconstituted with human immune cells such as PBMCs to produce humanized rats, the ImmunoRat™ – is in development for immune-oncology studies and in pharmacology and toxicology with a humanized hepatocyte SRG Model – HepatoRat™. Hera and its collaborators continue to develop additional applications of the SRG Platform. Please contact us if you have questions about applications outside of oncology and immune-oncology.