Hera Biolabs is an innovative preclinical service and technology provider with novel gene-editing and rat model creation technologies. We created the SRG™ rat, the first commercially available highly immunocompromised rat model, which has been validated for oncology and used routinely for human tumor xenograft studies (OncoRat^®). We also have our own proprietary gene-editing technologies, piggyBac transposon and the Cas-CLOVER targeted nuclease system, platforms used for cell-line modification and animal model creation. Hera makes available to researchers in academia and industry our gene-editing technologies and products, as well as our SRG rat. Hera also provides services in these areas, performing cell engineering and in vitro and in vivo oncology studies for clients. Hera conducts all work with excellent scientific rigor and customer service at our laboratories, with a state-of-the art vivarium, in beautiful Lexington, KY.

“The tumor uptake rate was to 80-100%, which is a huge advantage because what we could achieve as a statistical significance with 8-12 mice, can be achieved with 5-6 OncoRats.” — Ramesh Narayanan, Ph.D., Associate Professor of Medicine & Hematology at the University of Tennessee Health Science Center.

“(The) Cas-CLOVER hybrid gene editing system fuses a functionally inactive Cas9 to the site-specific nuclease, Clo51. Cas-CLOVER is targeted using a set of two distinct gRNAs, operating like CRISPR-Cas9, but (the) system has the exquisite specificity of type IIS nucleases and causes no or very few off-target mutations. We can use this high-fidelity system to safely develop off-the-shelf CAR T-cell products.” Devon J. Shedlock, Ph.D., vice president, preclinical development, Poseida Therapeutics. GEN Article True CRISPR: A Genetic Genre with Novel Twists