Preclinical Oncology Insights

The OncoRat® is the ideal host for patient-derived xenografts of ovarian cancer cells

Ovarian cancer is the most lethal gynecological cancer in the [...]

By Madeline Gober|2018-12-11T19:18:52+00:00December 11th, 2018|Tags: Analise DiFeo, Cancer, Cancer Xenografts, Cell Line Xenografts, Chemo-induced stemness, drug discovery, drug resistance, gynecological Cancer, Hera Biolabs, Humanized Rats, Immunodeficient Rats, in vivo model, NSG Mice, Oncology, oncology models, OncoRat, OV81, OV81.2, ovarian cancer, preclinical, rat model, TCGA, The Cancer Genome Atlas, Xenografts|

Evolution of the rat model

Rats have been favored for drug development studies because the [...]

By Madeline Gober|2018-12-14T19:32:48+00:00November 16th, 2018|Tags: Cancer, Cancer Xenografts, Cell Line Xenografts, Evolution, Hera Biolabs, Human Xenografts, Humanized Rats, Immunodeficient Rats, in vivo model, Non Small Cell Lung Cancer, NSCLC, Nude Rat, Nude Rats, Oncology, oncology models, OncoRat, preclinical, rat model, SCID Mice, SCID Rats, SDR Rats, Sprague Dawley Rat, Xenografts|

H358 NSCLC xenografts in humanized rats: the ideal in vivo model for studying KRAS mutations

Lung adenocarcinomas, the major histological subtype of non-small cell lung [...]

By Madeline Gober|2018-12-14T19:36:28+00:00October 20th, 2018|Tags: BRAF, Cancer, Cancer Xenografts, Cell Line Xenografts, EGFR, ERK, H358, Hera Biolabs, Humanized Rats, Immunodeficient Rats, in vivo model, KRAS, MEK, NCI-H358, Non Small Cell Lung Cancer, NSCLC, Oncogene, oncogene addiction, Oncology, oncology models, OncoRat, preclinical, rat model, Xenografts|

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Hera Biolabs announces Molecular Cancer Therapeutics publication on immunodeficient rats for oncology research
News

Hera Biolabs announces Molecular Cancer Therapeutics publication on immunodeficient rats for oncology research

Hera Biolabs, the University of Michigan, Case Western Reverse University [...]

By Madeline Gober|2019-01-08T18:55:29+00:00October 19th, 2018|

Breakthroughs in gene editing allows for the creation of superior preclinical oncology models

Gene editing is getting a lot of attention in the [...]

By Madeline Gober|2018-12-05T20:11:23+00:00September 30th, 2018|Tags: breakthroughs, Cancer, CRISPR, drug discovery, gene editing, gene therapy, Genetically eengineered, Genomic Editing, Hera Biolabs, humanized immune system, Oncology CRO, Oncology CROs, oncology models, OncoRat, PDX studies, piggyBac, preclinical, rat model, SDR rat, Sprague Dawley Rat, TALEN|

The OncoRat®: Hosting valuable tumor xenograft models that are difficult or impossible to study using in vitro or mouse models

One of the most widely used methods of modeling human [...]

By Madeline Gober|2018-12-14T19:31:47+00:00September 18th, 2018|

Patient derived xenograft studies from wider varieties of patient sub-populations promise improved clinical trial selection and design

Around 85% of preclinical drugs entering clinical trials in oncology [...]

By Madeline Gober|2018-12-14T19:26:52+00:00August 9th, 2018|

OncoRat® PDX models highlighted in Drug Discovery News (DDN) Special Report on Cancer: Aiming for Avatars

While advances in in-vitro platforms have allowed researchers to better [...]

By studio2108|2018-12-14T19:34:52+00:00July 18th, 2018|

Hera Biolabs to present at the 2018 AACR Annual Meeting.

Hera Biolabs will be presenting xenograft, PDX, and humanization of [...]

By Jack Crawford|2018-04-12T20:00:12+00:00April 12th, 2018|

Understanding Transporter-Mediated Drug-Drug Interactions Using Humanized Liver Mice

Pharmaceutical researchers and regulators are increasingly aware of the influence [...]

By Jack Crawford|2018-01-31T16:23:27+00:00January 31st, 2018|

Using Patient Derived Xenografts to Improve Therapeutic Cancer Treatments

An increased understanding of human tumors has created a solid [...]

By Jack Crawford|2018-01-30T18:22:23+00:00January 30th, 2018|

Humanized immune-system SRG Rats™ & mice for immuno-oncology

The SRG rat demonstrates robust immune-system humanization with peripheral blood [...]

By Jack Crawford|2018-01-29T22:20:28+00:00January 29th, 2018|

Humanized Mouse Models Advance Immunotherapeutic Strategies in Treatment of Type 1 Diabetes

A relatively common autoimmune disease, Type 1 Diabetes (T1D) is [...]

By Hera BioLabs|2018-07-23T16:52:14+00:00October 17th, 2017|

Humanized Mouse Models Advance Immunotherapeutic Strategies in Treatment of Type 1 Diabetes

A relatively common autoimmune disease, Type 1 Diabetes (T1D) is [...]

By Hera BioLabs|2017-10-19T14:52:54+00:00October 17th, 2017|

Using Cell Sheet Technique to Study the Development of HCC in Rat Models

As the single most prevalent primary liver cancer and the [...]

By Hera BioLabs|2017-10-17T17:44:30+00:00October 17th, 2017|

Understanding Circadian Rhythms in Humanized Mice

The human body’s circadian rhythm can significantly impact many biological [...]

By Hera BioLabs|2017-10-17T00:12:28+00:00October 17th, 2017|

Humanized Mice as Preclinical Models for Liver Stage Malaria Infection

Malaria continues to affect 250 million people around the world [...]

By Hera BioLabs|2017-05-31T18:10:45+00:00May 31st, 2017|

HIS Mice Provide New Preclinical Model for Human Skin Immunity

Despite the convenience and appeal of oral therapies, the reality [...]

By Hera BioLabs|2017-05-31T18:14:36+00:00May 31st, 2017|

What’s Old is New Again: Chemical Carcinogenesis Models of Cancer

Early cancer research focused primarily on chemical carcinogenesis in rat [...]

By Hera BioLabs|2017-05-31T18:16:27+00:00May 31st, 2017|

Hera Presents at SOT 2017 & AACR 2017 Recap

Hera strives to provide its clients with superior preclinical toxicology [...]

By Hera BioLabs|2017-05-01T19:42:38+00:00April 27th, 2017|

Chimeric Humanized Mouse Models: Understanding Human and Mouse Cell Interactions

Humanized liver mouse models are increasingly being used in preclinical [...]

By Hera BioLabs|2017-02-28T20:13:03+00:00February 28th, 2017|

Transposon Mutagenesis Helps Identify Genes Mediating Drug Resistance in the Treatment of CLL

First time treatment of Chronic Lymphocratic Leukemia (CLL) generally requires [...]

By Hera BioLabs|2017-05-02T19:14:59+00:00February 28th, 2017|

PDX Models of Lung Cancer Closely Mimic Characteristics of Patient Primary Tumors

Despite ongoing research, lung cancers have remained among the most [...]

By Hera BioLabs|2017-02-28T19:36:28+00:00February 28th, 2017|

Rat Provides a More Robust & Convenient Animal Infection Model for Hepatitis E Virus

Hepatitis E virus (HEV) is estimated to cause more than [...]

By Hera BioLabs|2016-12-23T14:55:34+00:00December 21st, 2016|

Hera BioLabs, a KY based contract research lab announces $400K Kentucky SBIR/STTR Matching Funds Grant

Hera BioLabs (“Hera”), a Lexington KY based contract research organization [...]

By Hera BioLabs|2016-12-14T16:05:34+00:00December 14th, 2016|

Transgenic Rats as Research Models Boast Significant Benefits….

Transgenic Rats as Research Models Boast Significant Benefits over Mouse [...]

By Hera BioLabs|2016-12-13T20:01:08+00:00November 30th, 2016|

Humanized Mouse Xenograft Models: The Best of Both Worlds

Xenograft rodent models and cultured cells have long been used [...]

By Hera BioLabs|2016-11-30T02:27:14+00:00November 30th, 2016|

Xenograft Rat Models Give Hope to New Therapeutic Treatments for Leukemia

Mutations in DNA methyltransferase 3A (DNMT3A) are common in acute [...]

By Hera BioLabs|2016-12-13T20:59:49+00:00November 30th, 2016|

Hera BioLabs in Genetic Engineering News

Hera BioLabs and our VP of Research and Development Tseten [...]

By Hera BioLabs|2016-10-31T20:45:38+00:00October 28th, 2016|

Advancements in Stem Cell-Based Therapies for Malignant Brain Tumors

Despite many great developments in the overall treatment of cancers, [...]

By Hera BioLabs|2016-12-13T20:38:36+00:00October 26th, 2016|

Hera BioLabs Receives PHS Approved Animal Welfare Assurance

Hera BioLabs, Inc. (Lexington KY) announced today that it has [...]

By Hera BioLabs|2016-09-16T00:29:40+00:00September 16th, 2016|

Humanized Rodent Models: A Critical Research Tool

Chimeric humanized liver rodent models are being used by those [...]

By Hera BioLabs|2016-09-30T15:04:20+00:00September 16th, 2016|

Lexington based toxicology lab, Hera BioLabs, partners with the NIH to use firefly proteins for drug discovery research

Hera BioLabs, a Lexington based contract research organization (CRO), announced [...]

By Hera BioLabs|2016-09-05T20:34:50+00:00May 10th, 2016|

Hera BioLabs, Inc. licenses SH-SY5Y neuroblastoma cell line and introduced neurotoxicity services

Lexington, KY - February 25, 2016 – Hera BioLabs, Inc. [...]

By Hera BioLabs|2016-09-05T20:34:57+00:00February 25th, 2016|

Hera to exhibit and present at the 2016 SOT ToxExpo

Hera will be located at booth 1103 of the SOT [...]

By Hera BioLabs|2016-01-28T16:26:50+00:00January 28th, 2016|

Hera presents at the 2015 American College of Toxicology

Hera to present at the 2015 American College of Toxicology [...]

By Hera BioLabs|2015-12-11T21:15:58+00:00October 12th, 2015|