The SRG rat is a SCID model created through knockout mutations in the Rag2 and Il2rgamma genes that result in a loss of mature B, T, and NK cells. the SRG Rat has an immunodeficient phenotype ideal for the engraftment of human tissue.
Taking advantage of the Sprague Dawley background and the larger organism size, SRG users have found our rats uniquely optimal for combining efficacy, pharmacokinetic (PK), biomarker, and toxicology related endpoints.
Boost your preclinical oncology research with our SRG Rat model delivered directly from our colony maintained with the highest health standard at the Charles River Labs GEMS facility.
Contact us to learn more.