Superior Oncology Xenograft Models: Why OncoRat is a Better Trap for Cancer

Poor engraftment efficiencies in SCID mice and athymic rats have plagued anticancer studies since the technology’s introduction. Inefficient oncology xenograft models lead to increased research costs,extended timelines, and lower the probability of study success. The SRG OncoRat model system sets an entirely new standard for translational research, delivering ~80-100% engraftment in a more favorable rat model where tumors grow faster, more efficiently, and larger than those of mouse models. Download the White Paper summarizing the recent Clinical Cancer Research paper featuring the OncoRat!

SRG OncoRat Technology: More Reliable, More Robust, More Efficient

SRG OncoRat , developed using Hera Biolabs’ technology, is a SCID rat on the Sprague-Dawley background that harbors a double knockout for the Rag2 and Il2rgamma genes. Similar to NSG mice, OncoRat demonstrates enhanced immunodeficiency, lacking B-cells, T-cells, and NK-cells. Combining these genetic changes in this immunodeficient rat allows the use of fewer animals through enhanced engraftment rates and improved tumor growth profiles for both cell-line tumor models and patient-derived xenografts (PDXs) (Figure 1). Given the many advantages of using SCID rats, OncoRat is an ideal model for combining efficacy, pharmacokinetic (PK), biomarker, and toxicology-related endpoints.

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Figure 1: OncoRat SRG enhances engraftment efficiency and reduces the number of animals needed.

Timely and Precise Data

SCID rats also have another clear benefit for translational physiology and toxicology studies: size. Specifically, their larger mass allows more options for dose administration (e.g., continuous infusions, devices).  For data collection, OncoRat can sustain serial blood sampling and serial tumor biopsies from the larger tumors grown. Ultimately, this enables richer PK and biomarker metrics over time. There’s no need to remove animals from studies or run studies in both mice and rats, as is the case with many oncology xenograft models. Researchers can use the same rats to complete a single time-course experiment.
For more information, check out the video below and recent publications featuring OncoRat SRG.