LNCaP prostate cells are broadly utilized as an AR sensitivity model in vitro but due to a low engraftment rate of 50% or less in mouse it is not fully utilized in vivo. In contrast, Hera BioLabs’ OncoRat displays 100% engraftment rates with consistent growth kinetics. The OncoRat also enables serial blood draws, allowing for PSA biomarker analysis and a smooth transition from efficacy to safety.
Ask us about pilots, full efficacy studies or getting OncoRat in your facility.
LNCaP tumor growth kinetics and weekly PSA levels in the SRG OncoRat. Ten million LNCaP cancer cells were transplanted subcutaneously in the SRG rat. Take rate was 100%. Left graph: Tumor volume over time; each line represents a single animal. Right graph: Serum PSA assessed weekly throughout the study. Each line represents an individual animal. Colors in tumor growth graph correspond to those in PSA graph.