Breakthroughs In Gene Editing Allow For The Creation Of Superior Preclinical Oncology Models
Gene editing is getting a lot of attention in the [...]
The OncoRat®: Hosting Valuable Tumor Xenograft Models That Are Difficult Or Impossible To Study Using In Vitro Or Mouse Models
One of the most widely used methods of modeling human [...]
Patient Derived Xenograft Studies From Wider Varieties Of Patient Sub-Populations Promise Improved Clinical Trial Selection And Design
Around 85% of preclinical drugs entering clinical trials in oncology never make it past Phase 1 because they fail to demonstrate sufficient efficacy due to testing in unselected patient populations 1-3. Many of these failed agents are targeted therapies, meaning that they target specific oncogenic driver mutations. However, not all tumors harbor the same, or even similar, driving mutations – these targeted therapies are often found to be beneficial in very small patient populations which would not be captured in an unselected-patient trial design.
OncoRat® PDX Models Highlighted In Drug Discovery News (DDN) Special Report On Cancer: Aiming For Avatars
While advances in in-vitro platforms have allowed researchers to better visually monitor a variety of aspects of tumor biology, a significant limitation of 3D cultured models for patient therapeutic monitoring or “patient avatars” is the lack of important components, such as the influence of surrounding tissues and potential cell-to-cell interactions, when studying cancer progression, treatment responses and outcomes. Patient derived xenograft models or PDX models overcome these limitations and other research challenges and provide a platform that is believed to more closely mimic the patient tumor.
Understanding Transporter-Mediated Drug-Drug Interactions Using Humanized Liver Mice
Pharmaceutical researchers and regulators are increasingly aware of the influence [...]
Using Patient Derived Xenografts To Improve Therapeutic Cancer Treatments
An increased understanding of human tumors has created a solid [...]
Humanized Immune-System SRG Rats™ & Mice For Immuno-Oncology
The SRG rat demonstrates robust immune-system humanization with peripheral blood [...]
Humanized Mouse Models Advance Immunotherapeutic Strategies In Treatment Of Type 1 Diabetes
A relatively common autoimmune disease, Type 1 Diabetes (T1D) is [...]
Humanized Mouse Models Advance Immunotherapeutic Strategies In Treatment Of Type 1 Diabetes
A relatively common autoimmune disease, Type 1 Diabetes (T1D) is [...]
Humanized Mice Allow For Better Understanding Of Interactions Between VACV & Immune System
Cancer is responsible for approximately 8 million deaths worldwide, with [...]