The SRG Rat – Xenograft Services

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The SRG Rat^®

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Sprague Dawley-Rag2^em2heraIl2rg^em1hera/HblCrl

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A Highly Immunodeficient Rat Strain for Xenograft Studies

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The SRG rat is a SCID model created through knockout mutations in the Rag2 and Il2rgamma genes that result in a loss of mature B, T, and NK cells. the SRG Rat has an immunodeficient phenotype ideal for the engraftment of human tissue.

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Taking advantage of the Sprague Dawley background and the larger organism size, SRG users have found our rats uniquely optimal for combining efficacy, pharmacokinetic (PK), biomarker, and toxicology related endpoints.

Get the most out of the SRG Rat model by leveraging our preclinical oncology expertise. In the hands of our seasoned researchers, the rat can deliver robust data, faster.

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What’s Unique About The SRG Rat Model?

We wield and sell disruptive biotechnology like the SRG OncoRat and gene editing technologies like Cas-CLOVER and piggyBac to efficiently and accurately run and enable contracted drug testing, drug discovery and development, chemical toxicity testing, and xenograft studies.

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Xenograft & PDX Studies

Hera provides in vivo oncology studies in our SRG rat in wide variety of xenograft and PDX tumor models. Learn more about why researchers prefer our SRG rat over traditional mouse models.

Or request more information about our capabilities and expansive xenograft portfolio. Let our team of expert scientists advise on the selecting the perfect preclinical drug efficacy testing strategy.

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Exclusive SRG Distribution Partnership

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Hera has partnered with Charles River for the distribution of the SRG rat to the directly to the global research community. Now all rat orders will be placed with and fulfilled by Charles River.

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Validated Using Difficult Xenograft and Patient Derived Xenograft (PDX) Models

The SRG Rat has been validated using a wide range of xenografts that consistently demonstrate high tumor take rates with traditionally difficult to engraft cell lines, such as VCaP prostate cancer, H358 non-small cell lung cancer (NSCLC), and prostate, NSCLC, and ovarian PDX models.

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Additionally, humane endpoints allow for subcutaneously implanted xenograft and PDX models to reach 10X tumor volumes, up to >20,000 mm3, compared to mouse xenografts allowing for serial tumor sampling or faster PDX establishment.

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How Is The SRG Rat Better Than SCID Mice?

Through the use of the SRG Rat, researchers can collect more consistent, higher quality data that provides advantages for predicting success in the clinic.

Xenografts in the larger SRG Rat models can display vastly improved engraftment efficiencies, tumor size, growth, and tumor morphology across a number of human cancer cell lines and patient-derived tissues that are either not permissive or extremely inefficient in mice.

An added benefit is the ability of the rat to achieve more human-like physiologic and metabolic traits versus mice.

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Cancer Researchers Find Success With
SRG Rat Models

A team of researchers led by Dr. Ramesh Narayanan at the University of Tennessee partnered with Hera BioLabs to evaluate new therapeutics for castration-resistant prostate cancer (CRPC), targeting androgen receptors (ARs).

Given the need for prostate cancer xenografts which model high AR-expression amplification phenotype found in many CRPC patients, the SRG rat has high tumor take rates of prostate cancer xenograft cell lines such as LNCaP & VCaP (>90%) which are prohibitively inefficient in mouse. Hera has expanded our capabilities to include validated castration-resistant and enzalutamide-resistant models.

[/fusion_text][fusion_imageframe lightbox=”no” style_type=”none” hover_type=”none” bordersize=”0px” borderradius=”0″ align=”center” linktarget=”_self” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ hide_on_mobile=”no” class=”fullimg “] [/fusion_imageframe][fusion_button link=”http://herabiolabs.com/press/hera-biolabs-announces-exclusive-global-license-with-charles-river/” title=”Press Release” target=”_self” alignment=”center” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” color=”custom” button_gradient_top_color=”#19a64a” button_gradient_bottom_color=”#19a64a” button_gradient_top_color_hover=”#19a64a” button_gradient_bottom_color_hover=”#19a64a” accent_color=”#ffffff” accent_hover_color=”#ffffff” type=”flat” border_color=”#ffffff” border_hover_color=”#ffffff” size=”xlarge” stretch=”no” margin_top=”33px” margin_bottom=”0″ icon_position=”left” icon_divider=”no” animation_direction=”left” animation_speed=”1″]Learn 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Learn More By Downloading Our Case Study

“The tumor uptake rate was to 80-100%, which is a huge advantage because what we could achieve as a statistical significance with 8-12 mice, can be achieved with 5-6 OncoRats.”

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-Ramesh Narayanan, Ph.D.
Associate Professor of Medicine & Hematology
University of Tennessee Health Science Center

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Immunophenotype of the SRG Platform

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Analysis Of Immune Populations In SRG Rats

A) CD4+/CD8+ mature T cells are absent.
B) The spleen contains no mature B cells as demonstrated by lack of CD45R (B220)+/IgM+ cells.
C) The Il2rg knockout results in a reduced NK cell population in the spleen.

Comparison between Nude rats and the SRG rat show a severally reduced number of natural killer (NK) cells in the circulating blood.

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filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″][fusion_builder_row][fusion_builder_column type=”1_1″ layout=”1_1″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” center_content=”no” target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” order_medium=”0″ order_small=”0″ hover_type=”none” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”left” animation_speed=”0.3″ last=”true” border_position=”all” first=”true” min_height=”” link=””][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ title_link=”off” link_target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”hed1″ content_align=”center” size=”2″ text_shadow=”no” text_shadow_blur=”0″ gradient_font=”no” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ style_type=”default” animation_direction=”left” animation_speed=”0.3″]Additional Resources[/fusion_title][fusion_accordion type=”accordions” inactive_icon=”fa-angle-down fas” active_icon=”fa-angle-up fas” icon_boxed_mode=”yes” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”ctm-toggles dp-none” border_size=”1″ icon_box_color=”rgba(51,51,51,0)” icon_alignment=”right” toggle_hover_accent_color=”#1c6095″][fusion_toggle title=”Creating the SRG Rat” open=”no”]The SRG Platform, is a Sprague-Dawley rat with a double knockout for the Rag2 and Il2rgamma genes (SD-Rag2tm2hera Il2rgtm1hera ). SRG is a severely immunodeficient rat that lacks B-cells, T-cells, and NK-cells. The OncoRat® was the first model built on the SRG Platform and introduced to enable and accelerate xenograft efficacy studies.[/fusion_toggle][fusion_toggle title=”Background” open=”no”]Cutting-edge gene-editing technologies Cas-CLOVER™ and piggyBac™ enable Hera to precisely engineer animal models and cell systems. Due to limitations of mouse models for oncology and the improved translatability of rats; Hera set out to create the ultimate rat model for oncology. The SRG Rat Platform was created through targeted-nuclease mediated gene disruption of the rat Rag2 and II2rg genes. It contains an 8 bp deletion in the Rag2 gene causing defective V(D)J recombination preventing T cell and B cell development. SRG also has a 16 bp deletion in the Il2rg gene, which leads to a lack of cytokine signaling, resulting in defective lymphoid development. The combined mutations result in a SCID rat with loss of mature B, T, and NK cells.[/fusion_toggle][fusion_toggle title=”Phenotype & Applications” open=”no”]

The SRG has a SCID rat phenotype and accepts human tissue as a xenograft model. The SRG Rat (or OncoRat) has been validated with a wide range of xenograft models including patient derived xenografts (PDX) and consistently demonstrates improved tumor take-rates and delivers tumor sizes 10x that of mouse models in half the time. For translational research, the rat produces blood and tissue samples ten times larger than mice and is metabolically closer to humans. Since the rat is the preferred model for pharmacokinetics (PK) and toxicology, OncoRat is ideally suited for efficacy and PK/toxicology studies in the same animal.

The SRG Platform can also be reconstituted with human immune cells such as PBMCs to produce humanized rats, the ImmunoRat™ – is in development for immune-oncology studies and in pharmacology and toxicology with a humanized hepatocyte SRG Model – HepatoRat™.. Hera and its collaborators continue to develop additional applications of the SRG Platform. Please contact us if you have questions about applications outside of oncology and immune-oncology.

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sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″][fusion_builder_row][fusion_builder_column type=”1_1″ layout=”1_1″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” center_content=”no” target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” order_medium=”0″ order_small=”0″ hover_type=”none” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”left” animation_speed=”0.3″ last=”true” border_position=”all” first=”true” min_height=”” link=””][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ title_link=”off” link_target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”hed1″ content_align=”center” size=”2″ text_shadow=”no” text_shadow_blur=”0″ gradient_font=”no” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ style_type=”default” animation_direction=”left” animation_speed=”0.3″]Frequently Asked Questions[/fusion_title][fusion_text rule_style=”default” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” text_transform=”none” animation_direction=”left” animation_speed=”0.3″]

We have compiled answers to frequent questions about our novel SRG OncoRat®. If you still have questions, feel free to contact us.

[/fusion_text][fusion_accordion type=”accordions” inactive_icon=”fusion-prefix-icon-plus” active_icon=”fusion-prefix-icon-minus” icon_boxed_mode=”yes” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”ctm-toggles pad-tb dp-none” border_size=”1″ icon_box_color=”rgba(51,51,51,0)” icon_alignment=”right” toggle_hover_accent_color=”#1c6095″][fusion_toggle title=”What is the SRG Rat?” open=”no” class=”pad-tb”]

Lorem ipsum dolor sit amet, consectetur adipiscing elit. In eleifend elit in sapien viverra, non tincidunt enim varius. Nunc vehicula tellus ac libero dictum, quis aliquet velit fringilla. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. Integer in arcu semper leo vehicula euismod vitae eu mi. Etiam quis leo in mi scelerisque malesuada. Morbi tempor sit amet risus id hendrerit. Aliquam non iaculis nisi. Proin vel est urna.

[/fusion_toggle][fusion_toggle title=”What services does Hera provide?” open=”no” class=”pad-tb”]

[/fusion_toggle][fusion_toggle title=”What cancer types grow in the SRG rat?” open=”no” class=”pad-tb”]

[/fusion_toggle][fusion_toggle title=”Can the SRG rat be humanized? ” open=”no” class=”pad-tb”]

[/fusion_toggle][fusion_toggle title=”What are the applications of the SRG rat?” open=”no” class=”pad-tb”]

[/fusion_toggle][fusion_toggle title=”Can the SRG rat be used for continuous IV dosing?” open=”no” class=”pad-tb”]

[/fusion_toggle][fusion_toggle title=”How many cancer cells should I use for my xenograft/PDX?” open=”no” class=”pad-tb”]

[/fusion_toggle][fusion_toggle title=”Can I purchase SRG Rats for my research?” open=”no” class=”pad-tb”]

[/fusion_toggle][fusion_toggle title=”Do the SRG rats require a special diet or housing conditions?” open=”no” class=”pad-tb”]

[/fusion_toggle][fusion_toggle title=”Where Can I find SRG Rat Publications?” open=”no” class=”pad-tb”]

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Ready To Advance Your Research?

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The SRG Rat®

A Highly Immunodeficient Rat Strain for Xenograft Studies

What’s Unique About The SRG Rat Model?

Xenograft & PDX Studies

Exclusive SRG Distribution Partnership

Validated Using Difficult Xenograft and Patient Derived Xenograft (PDX) Models

How Is The SRG Rat Better Than SCID Mice?

Cancer Researchers Find Success With SRG Rat Models

Learn More By Downloading Our Case Study

Analysis Of Immune Populations In SRG Rats

Accelerate Your Pre-Clinical Cancer Research and Drug Development

The SRG Rat^®

Cancer Researchers Find Success With
SRG Rat Models