The OncoRat® is the ideal host for patient-derived xenografts of ovarian cancer cells

December 11th, 2018|Comments Off on The OncoRat® is the ideal host for patient-derived xenografts of ovarian cancer cells

Ovarian cancer is the most lethal gynecological cancer in the United States. Advances in cytotoxic, platinum-based chemotherapeutics combined with tumor resection surgery allows approximately 80% of these patients to achieve remission. Unfortunately, the vast majority [...]

Evolution of the rat model

November 16th, 2018|Comments Off on Evolution of the rat model

Rats have been favored for drug development studies because the metabolism and pharmacokinetic properties of drugs in rats are most similar to humans. Rats are also preferable for xenograft studies because they allow for tumor [...]

H358 NSCLC xenografts in humanized rats: the ideal in vivo model for studying KRAS mutations

October 20th, 2018|Comments Off on H358 NSCLC xenografts in humanized rats: the ideal in vivo model for studying KRAS mutations

Lung adenocarcinomas, the major histological subtype of non-small cell lung cancers (NSCLC), harbor oncogenic KRAS mutations in approximately 25% of cases. Many of the targeted therapies that have been studied and approved for the treatment [...]

Breakthroughs in gene editing allows for the creation of superior preclinical oncology models

September 30th, 2018|Comments Off on Breakthroughs in gene editing allows for the creation of superior preclinical oncology models

Gene editing is getting a lot of attention in the oncology field for its potential in gene therapy, but this only scratches the surface of its potential applications. Hera is now using it to fight [...]

The OncoRat®: Hosting valuable tumor xenograft models that are difficult or impossible to study using in vitro or mouse models

September 18th, 2018|Comments Off on The OncoRat®: Hosting valuable tumor xenograft models that are difficult or impossible to study using in vitro or mouse models

One of the most widely used methods of modeling human tumor biology for preclinical research is the use of xenografts. Xenografts are generated by implanting human tumor cells under the skin or directly into the [...]

Patient derived xenograft studies from wider varieties of patient sub-populations promise improved clinical trial selection and design

August 9th, 2018|Comments Off on Patient derived xenograft studies from wider varieties of patient sub-populations promise improved clinical trial selection and design

Around 85% of preclinical drugs entering clinical trials in oncology never make it past Phase 1 because they fail to demonstrate sufficient efficacy due to testing in unselected patient populations 1-3. Many of these failed [...]

Hera Biolabs to present at the 2018 AACR Annual Meeting.

April 12th, 2018|Comments Off on Hera Biolabs to present at the 2018 AACR Annual Meeting.

Hera Biolabs will be presenting xenograft, PDX, and humanization of the immune system data from our new immunodeficient OncoRat SRG model at the up coming AACR 2018 Annual Meeting.   POSTER: Title: The SRG Rat™: A [...]

Understanding Transporter-Mediated Drug-Drug Interactions Using Humanized Liver Mice

January 31st, 2018|Comments Off on Understanding Transporter-Mediated Drug-Drug Interactions Using Humanized Liver Mice

Pharmaceutical researchers and regulators are increasingly aware of the influence that transporters have on the pharmacokinetics of drugs. These transporter mediated drug-drug interactions (DDIs) can precipitate adverse reactions in patients and as a result, safety [...]

Using Patient Derived Xenografts to Improve Therapeutic Cancer Treatments

January 30th, 2018|Comments Off on Using Patient Derived Xenografts to Improve Therapeutic Cancer Treatments

An increased understanding of human tumors has created a solid foundation for the creation of new anti-cancer treatments (many of which involve antineoplastic compounds). And while many of these newly conceived drug therapies show profound [...]

Humanized Mouse Models Advance Immunotherapeutic Strategies in Treatment of Type 1 Diabetes

October 17th, 2017|0 Comments

A relatively common autoimmune disease, Type 1 Diabetes (T1D) is still not well understood. It is known that T1D is caused by immune destruction of insulin-producing β cells and although it is widely believed that [...]

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