The OncoRat®: Hosting valuable tumor xenograft models that are difficult or impossible to study using in vitro or mouse models

September 18th, 2018|Comments Off on The OncoRat®: Hosting valuable tumor xenograft models that are difficult or impossible to study using in vitro or mouse models

One of the most widely used methods of modeling human tumor biology for preclinical research is the use of xenografts. Xenografts are generated by implanting human tumor cells under the skin or directly into the [...]

Patient derived xenograft studies from wider varieties of patient sub-populations promise improved clinical trial selection and design

August 9th, 2018|Comments Off on Patient derived xenograft studies from wider varieties of patient sub-populations promise improved clinical trial selection and design

Around 85% of preclinical drugs entering clinical trials in oncology never make it past Phase 1 because they fail to demonstrate sufficient efficacy due to testing in unselected patient populations 1-3. Many of these failed [...]

Hera Biolabs to present at the 2018 AACR Annual Meeting.

April 12th, 2018|Comments Off on Hera Biolabs to present at the 2018 AACR Annual Meeting.

Hera Biolabs will be presenting xenograft, PDX, and humanization of the immune system data from our new immunodeficient OncoRat SRG model at the up coming AACR 2018 Annual Meeting.   POSTER: Title: The SRG Rat™: A [...]

Understanding Transporter-Mediated Drug-Drug Interactions Using Humanized Liver Mice

January 31st, 2018|Comments Off on Understanding Transporter-Mediated Drug-Drug Interactions Using Humanized Liver Mice

Pharmaceutical researchers and regulators are increasingly aware of the influence that transporters have on the pharmacokinetics of drugs. These transporter mediated drug-drug interactions (DDIs) can precipitate adverse reactions in patients and as a result, safety [...]

Using Patient Derived Xenografts to Improve Therapeutic Cancer Treatments

January 30th, 2018|Comments Off on Using Patient Derived Xenografts to Improve Therapeutic Cancer Treatments

An increased understanding of human tumors has created a solid foundation for the creation of new anti-cancer treatments (many of which involve antineoplastic compounds). And while many of these newly conceived drug therapies show profound [...]

Humanized Mouse Models Advance Immunotherapeutic Strategies in Treatment of Type 1 Diabetes

October 17th, 2017|0 Comments

A relatively common autoimmune disease, Type 1 Diabetes (T1D) is still not well understood. It is known that T1D is caused by immune destruction of insulin-producing β cells and although it is widely believed that [...]

Humanized Mouse Models Advance Immunotherapeutic Strategies in Treatment of Type 1 Diabetes

October 17th, 2017|0 Comments

A relatively common autoimmune disease, Type 1 Diabetes (T1D) is still not well understood. It is known that T1D is caused by immune destruction of insulin-producing β cells and although it is widely believed that [...]

Using Cell Sheet Technique to Study the Development of HCC in Rat Models

October 17th, 2017|0 Comments

As the single most prevalent primary liver cancer and the third leading cause of cancer related deaths worldwide, a hepatocellular carcinoma (HCC) diagnosis presents patients with an exceedingly poor long-term prognosis. Currently there are no [...]

Understanding Circadian Rhythms in Humanized Mice

October 17th, 2017|0 Comments

The human body’s circadian rhythm can significantly impact many biological processes, including, but not limited to, the efficacy and side effects associated with drug treatments; however, the molecular basis underlying the circadian control of human [...]

Humanized Mice Allow for Better Understanding of Interactions between VACV & Immune System

June 29th, 2017|0 Comments

Cancer is responsible for approximately 8 million deaths worldwide, with new cancer cases expected to rise by more than 25% over the next two decades. This means that now, more than ever, researchers are looking [...]

By |September 5th, 2016                                                                                                                Read More