Understanding Transporter-Mediated Drug-Drug Interactions Using Humanized Liver Mice

January 31st, 2018|Comments Off on Understanding Transporter-Mediated Drug-Drug Interactions Using Humanized Liver Mice

Pharmaceutical researchers and regulators are increasingly aware of the influence that transporters have on the pharmacokinetics of drugs. These transporter mediated drug-drug interactions (DDIs) can precipitate adverse reactions in patients and as a result, safety [...]

Using Patient Derived Xenografts to Improve Therapeutic Cancer Treatments

January 30th, 2018|Comments Off on Using Patient Derived Xenografts to Improve Therapeutic Cancer Treatments

An increased understanding of human tumors has created a solid foundation for the creation of new anti-cancer treatments (many of which involve antineoplastic compounds). And while many of these newly conceived drug therapies show profound [...]

Humanized Mouse Models Advance Immunotherapeutic Strategies in Treatment of Type 1 Diabetes

October 17th, 2017|0 Comments

A relatively common autoimmune disease, Type 1 Diabetes (T1D) is still not well understood. It is known that T1D is caused by immune destruction of insulin-producing β cells and although it is widely believed that [...]

Humanized Mouse Models Advance Immunotherapeutic Strategies in Treatment of Type 1 Diabetes

October 17th, 2017|0 Comments

A relatively common autoimmune disease, Type 1 Diabetes (T1D) is still not well understood. It is known that T1D is caused by immune destruction of insulin-producing β cells and although it is widely believed that [...]

Using Cell Sheet Technique to Study the Development of HCC in Rat Models

October 17th, 2017|0 Comments

As the single most prevalent primary liver cancer and the third leading cause of cancer related deaths worldwide, a hepatocellular carcinoma (HCC) diagnosis presents patients with an exceedingly poor long-term prognosis. Currently there are no [...]

Understanding Circadian Rhythms in Humanized Mice

October 17th, 2017|0 Comments

The human body’s circadian rhythm can significantly impact many biological processes, including, but not limited to, the efficacy and side effects associated with drug treatments; however, the molecular basis underlying the circadian control of human [...]

Humanized Mice Allow for Better Understanding of Interactions between VACV & Immune System

June 29th, 2017|0 Comments

Cancer is responsible for approximately 8 million deaths worldwide, with new cancer cases expected to rise by more than 25% over the next two decades. This means that now, more than ever, researchers are looking [...]

Humanized Mouse Model Allows for Study of Immune Response to Decellularized ECM Biomaterials

June 23rd, 2017|0 Comments

Humanized rodent models have been used extensively for studying autoimmune diseases, viral infections, xenogeneic transplantation and, more recently, allogenic stem cell transplantation; however, until now, researchers have not used these murine models for studies in [...]

CRISPR-Cas9-Mediated Genome Editing Offers Hope in Cure for HIV-1/AIDS

June 11th, 2017|0 Comments

For more than 20 years, HIV/AIDS patients have widely been treated with the “AIDS Cocktail”, also known as combined antiretroviral therapy (cART). And although this combination therapy has given individuals infected with HIV a considerably [...]

Humanized Mice as Preclinical Models for Liver Stage Malaria Infection

May 31st, 2017|0 Comments

Malaria continues to affect 250 million people around the world and causes more than half a million deaths each year. And especially given the global heath community’s current goal of malaria eradication (as opposed to [...]

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