Humanized Mice Allow For Better Understanding Of Interactions Between VACV & Immune System
Cancer is responsible for approximately 8 million deaths worldwide, with [...]
Humanized Mouse Model Allows For Study Of Immune Response To Decellularized ECM Biomaterials
Humanized rodent models have been used extensively for studying autoimmune [...]
Early Discovery In Rats And Humanized Rodents
Do you have a compound and want a quick and cost effective in vivo evaluation? We offer a range of preliminary in vivo capabilities as well as the ability to screen compounds in both traditional animal rodent models, such as Sprague-Dawley rats and genetically engineered models (custom services & in vivo liver gene delivery available) including “humanized” liver rodent models, which are immunodeficient animals in which the native liver has been ablated and then engrafted with human hepatocytes, which proliferate to restore the functioning liver.
Humanized Mice As Preclinical Models For Liver Stage Malaria Infection
Malaria continues to affect 250 million people around the world [...]
HIS Mice Provide New Preclinical Model For Human Skin Immunity
Despite the convenience and appeal of oral therapies, the reality [...]
What’s Old Is New Again: Chemical Carcinogenesis Models Of Cancer
Early cancer research focused primarily on chemical carcinogenesis in rat [...]
New Mouse Model Enables In Vivo Assessment Of Immunotherapies For Treating CGD
Chronic granulomatous disease (CGD) is best described as an immune [...]
Patient Derived Xenografts Possess Significant Advantages In The Study Of Urological Tumors
The more researchers learn about various cancers, the complexity of [...]
In Vivo Liver Gene Delivery
The in vivo delivery of transgenes into the liver of rats provide a rapid method for the creation of liver specific disease models, as well as gene therapy efficacy and toxicity testing models, without the time and cost for embryo modification and transgenic animal creation. By combining the highly efficient liver-targeting properties of rAAV with the piggyBac transposon, the transgene of interest stably integrates into the genome and is reliably expressed1.
Bacterial Carriers Offer New Hope In The Treatment Of Glioblastoma
Unlike many cancers, which have seen a tremendous increase in [...]