• Understanding Circadian Rhythms in Humanized Mice - The human body’s circadian rhythm can significantly impact many biological processes, including, but not limited to, the efficacy and side effects associated with drug treatments; however, the molecular basis underlying the circadian control of human immune cells has remained difficult to verify due to the restrictions related to human data collection and the lack of in vivo human-specific study platforms.… Continue Reading >
  • Humanized Mice Allow for Better Understanding of Interactions between VACV & Immune System - Cancer is responsible for approximately 8 million deaths worldwide, with new cancer cases expected to rise by more than 25% over the next two decades. This means that now, more than ever, researchers are looking for new, more effective cancer therapies to be used alone or in combination with more conventional treatments such as surgery, chemotherapy and radiation therapy. One… Continue Reading >
  • Humanized Mouse Model Allows for Study of Immune Response to Decellularized ECM Biomaterials - Humanized rodent models have been used extensively for studying autoimmune diseases, viral infections, xenogeneic transplantation and, more recently, allogenic stem cell transplantation; however, until now, researchers have not used these murine models for studies in the field of biomaterials. In their recent paper published in Biomaterials, Wang et al used a humanized mouse model to “assess the human immune response… Continue Reading >
  • Early Discovery in Rats and Humanized Rodents - Continue Reading >
  • CRISPR-Cas9-Mediated Genome Editing Offers Hope in Cure for HIV-1/AIDS - For more than 20 years, HIV/AIDS patients have widely been treated with the “AIDS Cocktail”, also known as combined antiretroviral therapy (cART). And although this combination therapy has given individuals infected with HIV a considerably improved quality of life and a significantly extended life expectancy, it requires patients to undergo ongoing and costly treatment to suppress HIV-1 replication and does… Continue Reading >
  • Humanized Mice as Preclinical Models for Liver Stage Malaria Infection - Malaria continues to affect 250 million people around the world and causes more than half a million deaths each year. And especially given the global heath community’s current goal of malaria eradication (as opposed to the past approach of merely keeping the parasite at bay), it is increasingly important for researchers to have access to a readily available, scalable in… Continue Reading >
  • HIS Mice Provide New Preclinical Model for Human Skin Immunity - Despite the convenience and appeal of oral therapies, the reality is that immunotherapies cannot be effectively administered by mouth due to the undesirable breakdown of important immunologically active proteins that would occur in the gastrointestinal (GI) tract. In particular, research shows that vaccine-based immunotherapy treatments are best administered via skin injections. However, until now researchers have really lacked an appropriate… Continue Reading >
  • What’s Old is New Again: Chemical Carcinogenesis Models of Cancer - Early cancer research focused primarily on chemical carcinogenesis in rat models and helped establish clear causal links between environmental chemicals and increased risk of cancer in exposed populations.  And although cancer research has gotten significantly more sophisticated over the past century, researchers are signaling that chemical carcinogenesis models of cancer are resurging in relevance once again.   Thanks to recent… Continue Reading >
  • New Mouse Model Enables In Vivo Assessment of Immunotherapies for Treating CGD - Chronic granulomatous disease (CGD) is best described as an immune deficiency caused by a genetic mutation that results in defects in the production of microbicidal reactive oxygen species (ROS) by phagocytes. As a result, patients suffering from CGD are highly susceptible to a variety of bacterial and fungal infections. Thus far, effective treatments for CGD have been limited. Stem cell… Continue Reading >
  • Patient Derived Xenografts Possess Significant Advantages in the Study of Urological Tumors - The more researchers learn about various cancers, the complexity of the human disease is becoming more obvious. For researchers to model this complexity ongoing studies involving patient derived xenograft (PDX) murine models continuously show significant advantages when compared to the conventional cell-line-derived xenograft (CDX) mice. According to Inoue, et al in a paper recently published in peer-reviewed journal, Nature Review Urology,… Continue Reading >