Custom Gene Editing

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Custom Cell Line Engineering

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Improved cell based studies for drug discovery and development with our proprietary and precise gene editing tools.

[/fusion_text][fusion_button link=”http://herabiolabs.com/contact-us/” color=”custom” size=”xlarge” stretch=”no” type=”flat” target=”_self” title=”Contact Us” button_gradient_top_color=”#19a64a” button_gradient_bottom_color=”#19a64a” button_gradient_top_color_hover=”#19a64a” button_gradient_bottom_color_hover=”#19a64a” accent_color=”#ffffff” accent_hover_color=”#ffffff” icon_position=”left” icon_divider=”no” animation_type=”0″ animation_direction=”left” animation_speed=”1″ alignment=”center” border_color=”#ffffff” border_hover_color=”#ffffff”]Contact Us[/fusion_button][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container background_color=”#ececf2″ background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_repeat=”no-repeat” background_position=”left top” video_aspect_ratio=”16:9″ video_mute=”yes” video_loop=”yes” fade=”no” border_style=”solid” padding_top=”36″ padding_bottom=”23″ hundred_percent=”no” equal_height_columns=”no” hide_on_mobile=”no” class=”sec1″ id=”cro” type=”legacy” border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px”][fusion_builder_row][fusion_builder_column type=”1_1″ type=”1_1″ layout=”1_1″ last=”true” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” animation_speed=”0.1″ border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”true” hover_type=”none” min_height=”” link=””][fusion_imageframe lightbox=”no” style_type=”none” hover_type=”none” bordersize=”0px” borderradius=”0″ align=”center” linktarget=”_self” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ hide_on_mobile=”no” class=”btm30″] [/fusion_imageframe][fusion_text]

Gene editing technology continues to shape drug discovery and development research. Scientists utilize these tools to not only edit DNA for purposes of cell and gene therapies, but also to study disease states and their molecular targets and pathways.

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We help researchers create cellular models to mimic and study diseases, and screen for the next therapeutic breakthrough. The combination of Cas-CLOVER™ for targeted editing and piggyBac® transposase for stable expression of any sized DNA enables unlimited capacity for model creation.

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Partner with us for experience in over 75 cell lines or order reagents, the choice is yours.

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Targeted And Effective Gene Editing With Cas-CLOVER

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One of our key gene editing tools is Cas-CLOVER, a cleaner CRISPR alternative, which serves as “molecular scissors” to introduce targeted double-strand breaks in genomic DNA for knockouts, knock-ins and base-pair edits.

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Such tools have a wide range of drug discovery and development applications including cell-line engineering, and animal model creation.

Cas-CLOVER More Precise Than CRISPR

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Cas-CLOVER is unique compared to other targeted gene editing tools as it combines the efficiency of CRISPR/Cas9 with the specificity of TALENs:

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High efficiency: Cas-CLOVER is recruited to the target site by guide RNAs (gRNAs) in a similar way as Cas9. However, the Cas9 is completely deactivated “dCas9” and only serves as a linker to our high efficiency proprietary dimeric nuclease Clo51.

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High specificity: Cas-CLOVER utilizes two gRNAs which recruit two dCas9-Clo51 nucleases to initiate targeted cleavage. The dCas9-Clo51 nuclease is fully dimeric, meaning activity or cutting only occurs where a pair of nucleases bind correctly to the on-target genomic DNA. This technology has demonstrated best-in-class specificity by deep sequencing and Guide-Seq read-outs.

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Easy to Use: The Cas-CLOVER technology can be integrated into any gene editing application or workflow with simple open-source design tools. With clear and independent issued intellectual property, Cas-CLOVER is simple, convenient, and accessible for R&D and commercial applications.

[/fusion_text][fusion_button link=”http://herabiolabs.com/contact-us/” title=”Request Gene Editing Services” target=”_self” alignment=”left” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”nbtn1″ color=”custom” button_gradient_top_color=”#19a64a” button_gradient_bottom_color=”#19a64a” button_gradient_top_color_hover=”#19a64a” button_gradient_bottom_color_hover=”#19a64a” accent_color=”#ffffff” accent_hover_color=”#ffffff” type=”flat” border_color=”#ffffff” border_hover_color=”#ffffff” size=”xlarge” stretch=”no” icon_position=”left” icon_divider=”no” animation_direction=”left” animation_speed=”1″]Request Gene Editing Services[/fusion_button][/fusion_builder_column][fusion_builder_column type=”1_2″ type=”1_2″ layout=”1_2″ last=”true” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_style=”solid” margin_bottom=”20px” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”false” spacing_left=”2%” hover_type=”none” min_height=”” link=””][fusion_imageframe image_id=”7372|full” custom_aspect_ratio=”100″ lightbox=”no” linktarget=”_self” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”fullimg” align_medium=”none” align_small=”none” align=”center” style_type=”none” hover_type=”none” bordersize=”0px” borderradius=”0″ caption_style=”off” caption_align_medium=”none” caption_align_small=”none” caption_align=”none” caption_title_tag=”2″ animation_direction=”down” animation_speed=”0.1″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″]http://herabiolabs.com/wp-content/uploads/2023/02/dCas-Clo051-Combination-Process-Demeetra-Graphic-021323.png[/fusion_imageframe][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_repeat=”no-repeat” background_position=”left top” video_aspect_ratio=”16:9″ video_mute=”yes” video_loop=”yes” fade=”no” border_style=”solid” padding_bottom=”100px” hundred_percent=”no” equal_height_columns=”yes” hide_on_mobile=”no” class=”sec3 zigzag-section” type=”legacy” flex_align_items=”stretch” border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px”][fusion_builder_row][fusion_builder_column type=”1_2″ type=”1_2″ layout=”1_2″ last=”false” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_style=”solid” margin_bottom=”20px” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”true” spacing_right=”2%” hover_type=”none” min_height=”” link=””][fusion_imageframe image_id=”7369|full” custom_aspect_ratio=”100″ lightbox=”no” linktarget=”_self” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”fullimg” align_medium=”none” align_small=”none” align=”center” style_type=”none” hover_type=”none” bordersize=”0px” borderradius=”0″ caption_style=”off” caption_align_medium=”none” caption_align_small=”none” caption_align=”none” caption_title_tag=”2″ animation_direction=”down” animation_speed=”0.1″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″]http://herabiolabs.com/wp-content/uploads/2023/02/2D-piggyBac-with-Labels-1.png[/fusion_imageframe][/fusion_builder_column][fusion_builder_column type=”1_2″ type=”1_2″ layout=”1_2″ last=”true” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_style=”solid” margin_bottom=”20px” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ class=”max463-left” border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”false” spacing_left=”2%” hover_type=”none” min_height=”” link=””][fusion_title size=”2″ content_align=”left” style_type=”none” class=”hed1 hedm”]

Large DNA Cargo Delivery & Footprint-Free Editing With piggyBac

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Need to create a stable cell line, transgenic animal or precise base-pair edit? piggyBac is a proven transposase + transposon DNA modification system which helps introduce small to very large genetic cargo stably into the genome, as well as remove genetic cargo in a scarless manner in transgenics and stable cell lines. piggyBac is non-viral, cost effective and very efficient.

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Applications & Case Studies

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Find related and up-to-date information and literature for our Cell Line Engineering service
including blogs, posters, presentations, webinars, and white papers.

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We Can Do It For You

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We have the expertise to adopt or modify existing cell culture methods for any cell line with our proprietary gene editing tools, with 75+ different cells edited by our staff.

[/fusion_text][fusion_button link=”http://herabiolabs.com/contact-us/” title=”Request Gene Editing Services” target=”_self” alignment=”left” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”nbtn1″ color=”custom” button_gradient_top_color=”#19a64a” button_gradient_bottom_color=”#19a64a” button_gradient_top_color_hover=”#19a64a” button_gradient_bottom_color_hover=”#19a64a” accent_color=”#ffffff” accent_hover_color=”#ffffff” type=”flat” border_color=”#ffffff” border_hover_color=”#ffffff” size=”xlarge” stretch=”no” icon_position=”left” icon_divider=”no” animation_direction=”left” animation_speed=”1″]Request Gene Editing Services[/fusion_button][/fusion_builder_column][fusion_builder_column type=”1_2″ type=”1_2″ layout=”1_2″ last=”true” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_style=”solid” margin_bottom=”20px” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”false” spacing_left=”2%” hover_type=”none” min_height=”” link=””][fusion_imageframe lightbox=”no” style_type=”none” hover_type=”none” bordersize=”0px” borderradius=”0″ align=”center” linktarget=”_self” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ hide_on_mobile=”no” class=”fullimg”] [/fusion_imageframe][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container type=”legacy” hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”stretch” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”yes” container_tag=”div” hide_on_mobile=”small-visibility” status=”published” class=”sec3 zigzag-section zigzag-section-reverse” id=”zigzag-section-middle” padding_top=”0″ padding_bottom=”100px” border_sizes_top=”0px” border_sizes_right=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″][fusion_builder_row][fusion_builder_column type=”1_1″ type=”1_1″ layout=”1_1″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” center_content=”no” target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” order_medium=”0″ order_small=”0″ hover_type=”none” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”left” animation_speed=”0.3″ last=”true” border_position=”all” first=”true” min_height=”” link=””][fusion_accordion hide_on_mobile=”small-visibility,medium-visibility,large-visibility” border_size=”1″][fusion_toggle title=”Selecting the Right CRO for Gene Editing” open=”no” title_font_size=”11″]

A Guide to Selecting Your Ideal Contract Research Organization (CRO) for Gene Editing Services

As the life sciences field continues its rapid evolution, the potential for groundbreaking advancements in biotechnology, including genome editing, becomes increasingly tangible. Innovations leveraging the power of CRISPR-Cas9 have propelled gene-editing companies to the forefront, offering new horizons for understanding and treating genetic diseases. However, navigating this scientific frontier requires a knowledgeable partner, specifically a reliable Contract Research Organization (CRO). Here’s how to choose the right one for your needs.

Defining Your Project’s Landscape

Understanding the terrain of your project is paramount in selecting the appropriate CRO. Are you focusing on correcting mutations linked to specific diseases like sickle cell disease or beta thalassemia? Are you interested in cell therapies or next-generation treatments for conditions like amyloidosis? Recognizing your precise needs will help you identify a CRO proficient in those areas.

Exploring Technological Innovation

In the life sciences and biotech industry, innovation is the key. Look for a CRO that’s not only familiar with CRISPR-Cas9 and other gene-editing techniques but also stays up-to-date with the latest advancements like base editing. If your project involves novel treatments like CAR-T cell therapies, you’ll need a CRO at the cutting edge of these transformative developments.

Experience in Genome Editing

The efficacy of a CRO can often be determined by their track record in genome editing projects. Prior success is a testament to their ability to apply complex technologies such as CRISPR for precise genetic modifications. Such experience can be invaluable in advancing your project, whether you aim to explore gene function or pioneer new therapies.

Quality and Regulatory Compliance

A crucial aspect to consider is the CRO’s commitment to quality assurance and regulatory compliance. Given the stringent FDA regulations around gene-editing applications, especially those intended for clinical trials, you must ensure that your chosen CRO abides by these rigorous standards.

Communication and Partnership

Transparent and timely communication is crucial to the success of your partnership with a CRO. The organization should be prepared to collaborate effectively, offering an open dialogue throughout the course of your project. Such a symbiotic relationship will foster innovation and ensure alignment with your project’s objectives.

In Conclusion

Embarking on a journey through the terrain of life sciences, specifically gene editing, is thrilling yet complex. By taking these key factors into account, you can confidently select a CRO that not only possesses the technical prowess to navigate the field of gene editing, but also shares your passion for harnessing the power of biotechnology to catalyze scientific breakthroughs and develop potential life-saving treatments.

Remember, your choice of a CRO is more than a business decision—it’s a crucial partnership in your quest to reshape the future of healthcare and improve lives through revolutionary therapies. Let the right partner guide you through this exhilarating journey of exploration and discovery.

[/fusion_toggle][/fusion_accordion][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container background_color=”#bad4e8″ background_image=”http://herabiolabs.com/wp-content/uploads/2021/01/DNA.jpeg” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_repeat=”no-repeat” background_position=”left top” video_aspect_ratio=”16:9″ video_mute=”yes” video_loop=”yes” fade=”no” border_style=”solid” padding_top=”80px” padding_bottom=”50px” hundred_percent=”no” equal_height_columns=”yes” hide_on_mobile=”no” class=”sec3″ id=”aaalac” type=”legacy” flex_align_items=”stretch” border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px”][fusion_builder_row][fusion_builder_column type=”1_1″ type=”1_1″ layout=”1_1″ last=”true” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_repeat=”no-repeat” background_position=”left top” border_position=”all” border_style=”solid” margin_bottom=”20px” animation_type=”0″ animation_direction=”down” animation_speed=”0.1″ border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px” first=”true” hover_type=”none” min_height=”” link=””][fusion_title size=”2″ content_align=”left” style_type=”none” class=”hed1 hedm”]

Advanced Gene Editing Tools Made Accessible

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The work products from our custom services typically come with a full research license. We are also offering clear commercial freedom to operate and simple accessible licenses for commercial applications in drug discovery.

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Accelerate Your Pre-Clinical Research With The Right Tools

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Let us help you use precise gene editing tools for your drug discovery and development research. Contact us to learn more.

[/fusion_text][fusion_button link=”http://herabiolabs.com/contact-us/” color=”custom” size=”xlarge” stretch=”no” type=”flat” target=”_self” title=”Schedule A Call” button_gradient_top_color=”#19a64a” button_gradient_bottom_color=”#19a64a” button_gradient_top_color_hover=”#19a64a” button_gradient_bottom_color_hover=”#19a64a” accent_color=”#ffffff” accent_hover_color=”#ffffff” icon_position=”right” icon_divider=”no” animation_type=”0″ animation_direction=”left” animation_speed=”1″ alignment=”left” border_color=”#ffffff” border_hover_color=”#ffffff”]Schedule A Call[/fusion_button][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container type=”flex” hundred_percent=”no” hundred_percent_height=”min” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”center” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”no” container_tag=”div” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” status=”published” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”center center” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ background_image=”http://herabiolabs.com/wp-content/uploads/2023/12/cta-bg.jpg” min_height=”600″ padding_top=”80″ padding_bottom=”80″ min_height_medium=”400″ padding_top_medium=”60px” padding_bottom_medium=”60px” class=”fctaSec”][fusion_builder_row][fusion_builder_column type=”1_1″ type=”1_1″ layout=”1_1″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” center_content=”no” target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” order_medium=”0″ order_small=”0″ hover_type=”none” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”left” animation_speed=”0.3″ last=”true” border_position=”all” first=”true” min_height=”” link=””][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ title_link=”off” link_target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”secHeading” content_align=”center” size=”2″ fusion_font_family_title_font=”Montserrat” font_size=”66″ line_height=”1.1″ letter_spacing=”var(–awb-custom_typography_1-letter-spacing)” text_transform=”var(–awb-custom_typography_1-text-transform)” text_color=”#ffffff” text_shadow=”no” text_shadow_blur=”0″ gradient_font=”no” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ style_type=”default” animation_direction=”left” animation_speed=”0.3″ fusion_font_variant_title_font=”500″]

Ready To Advance Your Research?

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Let’s Talk

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