FULLY IMMUNODEFICIENT RAT MODEL
Our newly developed SRG™ rats have a double knockout of the Rag2 and Il2rg genes on a Sprague Dawley background and have a severely impaired immune system lacking B-cells, T-cells, and NK-cells. This model has the potential to overcome limitations of the less immunodeficient rat models and may have enhanced utility in comparison to severely immunodeficient mouse models. Below are some key applications and areas of development for the model.
Our Rag2 KO rat strain that we previously developed and is currently available has shown successful engraftment of cancer cells lines. For more information, download our whitepaper below.